Ahn Chang-hwan broke into the entertainment industry in 2015 through a minor role in the web series Dream Knight. This was followed by an appearance in the 2016 movie Grandfather. The following year, he became part of the cast of the top-rating tvN series Smart Prison Living. In 2019, he acted a supporting role in the SBS drama The Fiery Priest. In 2021, he was cast in the tvN sci-fi series L.U.C.A.: The Beginning. He also made a special appearance as a homeless man in the hit 2021 tvN dark comedy Vincenzo, which starred Song Joong-ki in the title role. He also joined the 2021 JTBC drama Monthly Magazine Home.

Ahn Chang-hwan is married to actress Jang Hee-jung.