Jisoo debuted with the South Korean girl group Blackpink in August 2016 with the single album Square One, which produced the hit songs Boombayah and Whistle. The group has since become one of the most successful South Korean acts worldwide with their fast-selling albums and sold-out concerts. In 2020, the group released their first full-length album called The Album, which debuted at number two on the U.S. Billboard 200. It spawned the singles How You Like That, Ice Cream, and Lovesick Girls. Ice Cream peaked at number 13 on the U.S. Billboard Hot 100, becoming the group’s highest-charting single in the United States. Jisoo co-wrote Lovesick Girls. The group also became the first K-pop girl group to achieve the “million seller” status after The Album sold over a million copies.

Prior to her debut with Blackpink, Jisoo appeared in the music videos for Epik High’s Spoiler + Happen Ending and Hi Sohyun’s I’m Different in 2014. She also made a cameo appearance in KBS2’s The Producers in 2015. In 2021, she made her acting debut as the female lead of the JTBC series Snowdrop, opposite Jung Hae-in.

Jisoo attended the School of Performing Arts Seoul. She is the youngest of three siblings. In August 2023, it was confirmed that she is dating actor Ahn Bo-hyun. They broke up two months later.