Choi Myung-bin debuted as an actress in the 2016 film Queen of Walking. In 2017, she played the young counterparts of female leads in various TV series such as tvN’s Chicago Typewriter and OCN’s Black. She also had appearances in the SBS series Return in 2018 and in the OCN drama Trap in 2019. In 2021, she was cast as Ji Hyun-woo’s eldest child in the high-rating KBS2 family weekend series Young Lady and Gentleman. That same year, she portrayed dual roles in the KBS2 sageuk The King’s Affection. Her work in both series won her Best Young Actress at the KBS Drama Awards. In 2022, she became part of the hit tvN drama Twenty Five, Twenty One.