Daniel Henney began his entertainment career as a model before making his television debut in the top-rating MBC romantic comedy My Name Is Kim Sam-soon in 2005. His work in the series won him Best New Actor at the MBC Drama Awards. The series also took home the Daesang for TV at the 42nd Baeksang Arts Awards. In 2006, Daniel Henney made his big screen debut in the South Korean romantic comedy Seducing Mr. Perfect. The following year, he starred in his second movie called My Father, in which he picked up numerous Best New Actor awards in South Korea. In 2009, he landed his first American role in the movie X-Men Origins: Wolverine. In 2012, he appeared in the American romantic comedy film Shanghai Calling, which won him acting awards at the Shanghai International Film Festival and the Newport Beach Film Festival. From 2016 to 2017, he played Special Agent Matt Simons in the American series Criminal Minds: Beyond Borders, which is a spin-off of Criminal Minds. He later joined Criminal Minds as a regular cast from season 13 to 15.

Daniel Henney’s mother is a Korean-American adoptee from Busan, South Korea while his father is an American of British decent.