Go Bo-kyul debuted in the 2011 movie Turtles. In 2014, she became part of the KBS2 daily drama Angel’s Revenge. In late 2016, she landed a supporting role in the hit tvN fantasy series The Lonely Shining Goblin, which was followed by appearances in the KBS2 dramas Seven Day Queen and Go Back Spouses in 2017. In 2018, she starred in an episode of the KBS Drama Special Season 9, in which she was nominated for Best Actress in a One-Act/Special/Short Drama at the KBS Drama Awards. In 2020, she was included in the main cast of the tvN series Hi Bye, Mama! In 2021, she won Best Actress at the Stockholm Film & Television Festival for an episode of tvN’s Drama Stage Season 4.

Go Bo-kyul attended the Seoul Institute of the Arts.