Han Ji-eun began her acting career in the 2010 movie Ghost and has since appeared in a number of series and films. In 2018, she played a gisaeng who has feelings for Kim Sun-ho’s character in the tvN sageuk 100 Days My Prince. In 2019, she landed a main role in the JTBC romantic comedy Be Melodramatic. In 2020, she became part of the MBC series Old School Intern, which was hailed Drama of the Year at the MBC Drama Awards. She was also nominated for an Excellence Award at the MBC Drama Awards for her performance in the series. Later in 2020, she acted alongside Ji Chang-wook and Kim Ji-won in the romance drama Lovestruck in the City, which premiered on KakaoTV.

Han Ji-eun dated rapper Hanhae. They went public with their relationship in August 2019 but parted ways in late 2020.