Han Ji-hyo made her entertainment industry debut in the 2019 web reality show Real High School Romance. This was followed by appearances in the web dramas Real:Time:Love and Crash! Insignificant Roommates. In 2020, she joined the MBC web series Pop Out Boy! In 2021, she was cast in main roles in two more web dramas called Durian Is Not a Fruit and High! Touch. She then played bit parts in Hospital Playlist 2 and in Work Later, Drink Now, which both aired on tvN. In 2022, she had cameos in the SBS romantic comedy Business Proposal and in the MBC fantasy Tomorrow. That same year, she starred in TVING’s Dear X Who Doesn’t Love Me, opposite NCT’s Doyoung.