Han So-eun debuted as an actress in the 2016 web series Gogh’s Starry Night. In 2018, she became part of KBS2’s TV Novel: Through the Waves as well as the web dramas Between Friendship and Love 3 and Number Six. In 2019, she was cast in a supporting role in the OCN series Class of Lies. In 2020, she played the teenage counterpart of Kim Haneul’s character in the JTBC series Eighteen Again, which was based on the 2009 American fantasy-comedy film 17 Again. In 2021, she starred in the JTBC music drama Idol: The Coup.

Han So-eun attended Dongduk Women’s University’s broadcasting and entertainment department.