Hwang Woo-seul-hye made her acting debut in the 2008 black comedy film Crush and Blush, which scored her Best New Actress nominations at the 29th Blue Dragon Film Awards and the 45th Baeksang Arts Awards. In 2010, she was nominated for Best Actress in a One-Act Drama/Special at the KBS Drama Awards for her performance in KBS Drama Special’s Our Slightly Risqué Relationship. In 2011, she appeared in the KBS2 weekend drama Believe in Love, which gave her a Best New Actress nomination at the KBS Drama Awards. In 2014, she became part of the main cast of the SBS family drama Feel-Good Day. In 2019, she played supporting roles in the hit tvN series Crash Landing on You and in MBC’s People With Flaws.

In July 2018, it was confirmed that Hwang Woo-seul-hye was dating a businessman. However, the couple ended their relationship just a few months later.