Jang Dong-gun made his acting debut in the 1992 MBC series Our Heaven. In 1994, he starred in the MBC sports drama The Last Match, which won him Best New Actor at the 30th Baeksang Arts Awards. In 1997, he landed his first film role in Repechage, which earned him the Best New Actor trophy at the 18th Blue Dragon Film Awards. That same year, he scored a Top Excellence Award at the MBC Drama Awards for his portrayal of a cold-blooded thoracic surgeon in Medical Brothers. In 1999, he joined director Lee Myung-se’s Nowhere to Hide, which gave him the Best Supporting Actor trophy at the 20th Blue Dragon Film Awards. In 2001, he appeared in the blockbuster action film Friend, in which he was named Best Supporting Actor at the 46th Asia Pacific Film Festival. In 2004, he received the Best Actor honors at the 25th Blue Dragon Film Awards for his work in the wartime action drama film Taegukgi: The Brotherhood of War. In 2012, he made his much-awaited return to the small screen in the SBS romantic comedy A Gentleman’s Dignity, in which he bagged a Top Excellence Award at the SBS Drama Awards. In 2018, he picked up an Excellence Award at the KBS Drama Awards for Suits, which was based on the American TV series of the same name. In 2019, he collected the Daesang at the 4th Asia Artist Awards for the hit tvN historical fantasy series Arthdal Chronicles.

Jang Dong-gun married his Love Wind Love Song leading lady Go-So-young in May 2010. They have a son and a daughter together. The actor is a baseball aficionado and is a member of the celebrity baseball team called The Playboys along with fellow actors Jung Woo-sung, Lee Jong-hyuk, and Hyun Bin, among others.