Kim In-kwon made his acting debut in the 1999 film Rainbow Trout. He then played supporting roles in several well-received movies such as Lee Chang-dong’s Peppermint Candy and Park Chan-wook’s Anarchists, which were both released in 2000. His work in the latter earned him a Best New Actor nomination at the 21st Blue Dragon Film Awards. In 2002, he directed the short film Shivski, in which he also starred. In 2007, he joined the hit SBC medical series Surgeon Bong Dal Hee, which gave him a Best Supporting Actor nomination at the SBS Drama Awards. In 2009, he became part of the disaster film Tidal Wave, which won him Best Supporting Actor at the 18th Buil Film Awards. In 2010, he was cast in his first leading role in the black comedy movie He’s on Duty. In 2012, he took home another Best Supporting Actor trophy, this time at the 3rd KOFRA Film Awards for the war film My Way. In 2014, he acted alongside Jung Woo-sung and Lee Beom-soo in the action film The Divine Move, which scored him a Best Supporting Actor nomination at the 51st Grand Bell Awards.

Kim In-kwon studied theater and film at Dongguk University. He married a childhood friend in 2004. They have three daughters together.