Lee Sun-bin began her entertainment career with a brief stint with the South Korean girl group JQT from 2011 to 2012. She promoted with the group under her real name. In 2014, she landed her first acting gig in the Chinese historical series Saint Wang Xizhi. She started to gain attention as an actress in 2016 when she became part of the hit OCN series Police Unit 38. In 2017, she appeared in MBC’s Missing 9, which won her Best New Actress at the MBC Drama Awards. That same year, she joined the main cast of tvN’s Criminal Minds, which was based on the American TV series of the same name. In 2018, she was cast in her first leading role in JTBC’s action romance drama Sketch. In 2021, she starred as a workaholic broadcast writer in the web series Work Later, Drink Now.

In 2018, it was confirmed that Lee Sun-bin and Lee Kwang-soo are dating. The two first met on the set of the SBS variety show Running Man in 2016.