Song Sang-eun made her screen debut in the 2017 comedy-drama film The Bros. In 2018, she became part of the KBS2 drama Your House Helper. In 2019, she was cast in JTBC’s The Light in Your Eyes. She also joined the tvN dramas Abyss and Catch the Ghost. In 2020, she appeared in several TV series such as SBS’s The King: Eternal Monarch and JTBC’s Private Lives. In 2021, she acted alongside Kim Ok-bin and Lee Jun-hyuk in the OCN thriller Dark Hole. In 2022, she played a supporting role in the Disney+ series Grid.

Song Sang-eun’s father Song Young-chang is also an actor.