Yang Jin-sung debuted as an actress in the 2010 drama film Wedding Dress. In 2011, she appeared in SBS’s City Hunter and in MBC’s Just Like Today. In 2013, she played a supporting role in the KBS2 melodrama Secret. That same year, she became part of director Lee Jun-ik’s film Hope. In 2014, she was cast in her first leading role in TV Chosun’s fantasy romance series Hundred Year Bride, opposite Lee Hong-ki. In 2015, she starred with Noh Min-woo in MBC Dramanet’s My Unfortunate Boyfriend. This was followed by another leading role in the 2016 SBS daily drama Marrying My Daughter Twice. In 2018, she joined the main cast of the tvN medical thriller Cross.

Yang Jin-sung studied fine arts at Ewha Womans University.