Yeom Hye-ran debuted as a stage actress before making her big screen debut in 2003 through director Bong Joon-ho’s acclaimed crime thriller film Memories of Murder. She landed her first television role in the 2016 tvN series Dear My Friends. That same year, she appeared in the hit tvN fantasy romance drama The Lonely Shining Goblin. In 2017, she became part of the film I Can Speak, which earned her Best Supporting Actress nominations at the 38th Blue Dragon Film Awards and the 54th Baeksang Arts Awards. In 2019, she joined the drama film Innocent Witness, which gave her two more Best Supporting Actress nominations. Later in 2019, she starred in the KBS2 series When the Camellia Blooms, which won her Best Supporting Actress at the KBS Drama Awards. In 2021, she was named Best Supporting Actress at the 57th Baeksang Arts Awards for her work in OCN’s The Uncanny Counter. She also received acting nominations at that year’s Wildflower Film Awards and Buil Film Awards for Black Light.

Yeom Hye-ran attended Seoul Women’s University.