Kim Woo-seok made his acting debut in the 2017 web series Love Playlist: Season 2. In 2018 and 2019, he played a supporting role in the second and third seasons of OCN’s hit crime-thriller Voice. In 2021, he was cast as one of the main characters in the web drama Scripting Your Destiny along with Ki Do-hoon and Jeon So-ni. That same year, he reprised his role in Voice 4. In 2022, he joined the Disney+ series Rookie Cops as well as tvN’s Military Prosecutor Doberman.

Kim Woo-seok majored in acting at the Seoul Institute of the Arts. His older brother Kim Min-seok is part of the South Korean duo MeloMance.