Heo Jun-ho began his acting career in theater before branching out into TV series and films. In 1995, he won Best Supporting Actor at the 16th Blue Dragon Film Awards for the box-office hit The Terrorist. In 2000, he received the Best Actor trophy at the 6th Korea Musical Awards for his portrayal of the leading role in Gambler. In 2003, he acted a supporting role in the top-rating SBS series All In, in which he was named Best Supporting Actor at the SBS Drama Awards. That same year, he starred in the blockbuster action drama film Silmido, which gave him the Best Supporting Actor trophy at the 41st Grand Bell Awards. In 2006, he took home a Special Acting Award at the MBC Drama Awards for his performance in the popular sageuk series Jumong. In 2018, he played a psychopath serial killer in MBC’s Come Here and Hug Me, in which he scored several acting awards and nominations. In 2021, he bagged a couple of Best Supporting Actor trophies for his work in the action drama film Escape from Mogadishu.

Heo Jun-ho’s father is the late actor Heo Jang-gang. His older brother Heo Gi-ho is also an actor.