Han Bo-reum made her acting debut in 2011 with a minor role in the KBS2 drama Dream High. In 2013, she landed a supporting role in the SBS horror romantic comedy Master’s Sun, which starred So Ji-sub and Gong Hyo-jin. In 2017, she played one of Jang Nara’s best friends in the KBS2 drama Go Back Spouses, which won her Best New Actress at the 25th Korea Culture and Entertainment Awards. In 2019, she landed her first leading role in the MBN office romantic comedy Level Up, opposite Sung Hoon. In 2020, she joined the cast of the KBS2 weekend drama Oh! Samkwang Villa.

In November 2016, it was confirmed that Han Bo-reum and FT Island’s Lee Hong-ki were dating. They met in 2014 on the set of the SBS series Modern Farmer. They broke up in early 2017.