Ki Do-hoon began his entertainment career as a model before bagging his first big screen appearance in the 2015 musical drama film C’est si bon. In 2017, he officially made his television debut in the MBC sageuk The King Loves, playing the bodyguard of Im Shi-wan’s character. In 2019, he was cast in supporting roles in the tvN dramas Arthdal Chronicles and Catch the Ghost. In 2020, his career received a boost when he became part of the popular KBS2 family drama Once Again. In 2021, he appeared in the second season of the hit Netflix series Love Alarm. That same year, he starred in the web series Scripting Your Destiny along with Jeon So-ni and Kim Woo-seok.