Ki Eun-se debuted as an actress in 2006 with a small role in the KBS2 series Invisible Man Choi Jang-soo. She then had a brief appearance in the 2008 film The Good, the Bad, the Weird. In 2012, she landed a main role in the SBS series The Musical. In 2013, she joined the romance drama Fashion King, which also aired on SBS. With little progress in her acting career, she rebranded herself and found success as a social media personality. Her solid Instagram following helped her secure collaborations with numerous brands. In 2019, she returned to the small screen with a supporting role in the KBS2 family drama What’s Wrong Mr. Poong-sang. In 2020, she became a main host of the TV Chosun home makeover show Homederella. That same year, she appeared in the hit SBS series Penthouse. In 2021, she was cast in several TV series such as KBS2’s River Where the Moon Rises and SBS’s Now, We Are Breaking Up.

Ki Eun-se married a Korean-American businessman in 2012.