Moon Sori began her acting career on stage before making her feature film debut in 2000 through director Lee Chang-dong’s Peppermint Candy. In 2002, she reunited with Lee Chang-dong in the psychological drama romance film Oasis. She bagged multiple acting citations for her performance in the movie, including Best Actress at the 29th Seattle International Film Festival. In 2003, she starred in the sexy drama film A Good Lawyer’s Wife, which earned her another set of Best Actress trophies. In 2006, she shared the Best Actress honors at the 47th Thessaloniki International Film Festival with he co-stars in the film Family Ties. In 2010, she acted alongside Kim Sang-kyung and Yoo Joon-sang in the comedy-drama movie Ha Ha Ha, which gave her the Best Actress trophy at the 19th Buil Film Awards. In 2017, she was named Best Supporting Actress at the 11th Asian Film Awards for director Park Chan-wook’s The Handmaiden. In 2020, she joined Kim Sun-young and Jang Yoon-ju in the drama film Three Sisters, which won her numerous Best Actress awards.

In 2014, Moon Sori made her debut as a director and screenwriter in the short film The Actress, in which she also starred. This was followed by two more short films in 2015, namely The Running Actress and The Best Director. In 2017, all her three short films were released as a feature film under the title The Running Actress, which scored her several acting and directing nominations.

Moon Sori attended Sungkyunkwan University. She married film director Jang Joon-hwan in December 2006. After a miscarriage in 2010, she and her husband welcomed their daughter in August 2011.